University of Saskatchewan
|Principal Research Scientist / Principal Investigator
Canada
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Jeffrey Chen
About
Work
École Polytechnique Fédérale de Lausanne
|CIHR and Canadian Thoracic Society post-doctoral fellow
Switzerland
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Education
University of Toronto
Canada
→
PhD
Dalhousie University
Canada
→
BSc (Honours)
Publications
Assembly of the Mycobacterium tuberculosis type VII ESX-1 secretion system in Mycobacterium smegmatis identifies a new transcriptional activator of esx-1 genes and a novel TB vaccine
Microbiology Spectrum
journal-article
The Parkinson's drug benztropine possesses histamine receptor 1-dependent host-directed antimicrobial activity against Mycobacterium tuberculosis.
npj antimicrobials and resistance
journal-article
Optimization and validation of ELISAs for interferon-gamma determination in bison.
Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc
journal-article
Orally administered live BCG and heat-inactivated Mycobacterium bovis protect bison against experimental bovine tuberculosis.
Scientific reports
journal-article
A recombinant bacterial strain as tuberculosis vaccine candidate and methods of producing thereof.
patent
Mycobacterium tuberculosis EspK has active but distinct roles in the secretion of EsxA and EspB
Journal of Bacteriology
journal-article
Mycobacterium tuberculosis EspK Has Active but Distinct Roles in the Secretion of EsxA and EspB
Journal of Bacteriology
journal-article
Pyrazole and Triazole Derivatives as Mycobacterium tuberculosis UDP-Galactopyranose Inhibitors
Pharmaceuticals
journal-article
Domestic pigs experimentally infected with Mycobacterium bovis and Mycobacterium tuberculosis exhibit different disease outcomes
Tuberculosis
journal-article
Protein Synthesis and Degradation Inhibitors Potently Block Mycobacterium tuberculosis type-7 Secretion System ESX-1 Activity
ACS Infectious Diseases
journal-article
A SNP in the Cache 1 Signaling Domain of Diguanylate Cyclase STM1987 Leads to Increased in vivo Fitness of Invasive Salmonella Strains.
Infection and immunity
journal-article
A SNP in the Cache 1 Signaling Domain of Diguanylate Cyclase STM1987 Leads to Increased In Vivo Fitness of Invasive Salmonella Strains
Infection and Immunity
journal-article
Poor stimulation of bovine dendritic cells by Mycobacterium bovis culture supernatant and surface extract is associated with decreased activation of ERK and NF-κB and higher expression of SOCS1 and 3.
Innate immunity
journal-article
Poor stimulation of bovine dendritic cells by Mycobacterium bovis culture supernatant and surface extract is associated with decreased activation of ERK and NF-κB and higher expression of SOCS1 and 3
Innate Immunity
journal-article
Novel approaches to tuberculosis vaccine development using novel animal models
The 5th International One Health Congress
conference-paper
Suppression of the ESX-1 system – mechanisms, consequences & implications
American Society for Microbiology Conference on Tuberculosis – Past, Present and Future
conference-paper
Mycosins of the Mycobacterial Type VII ESX Secretion System: the Glue That Holds the Party Together.
mBio
journal-article
Chemical Genetics of the M. tuberculosis ESX-1 Secretion System – from anti-virulence drugs to gene-function discovery
Department of Microbiology and Immunology Seminar Series - College of Medicine, University of Saskatchewan
lecture-speech
Mycobacterium tuberculosis EspD is a secreted virulence modulator
Canadian Society of Microbiologists 65th Annual Conference
conference-paper
The Type-7 ESX-1 Secretion System and Aerobiology of M. tuberculosis – prospective targets for TB therapy
Department of Chemistry and Biochemistry, University of Regina
lecture-speech
Anticytolytic screen identifies inhibitors of mycobacterial virulence protein secretion.
Cell host & microbe
journal-article
EspI regulates the ESX-1 secretion system in response to ATP levels in Mycobacterium tuberculosis.
Molecular microbiology
journal-article
The cysteine desulfurase IscS of Mycobacterium tuberculosis is involved in iron-sulfur cluster biogenesis and oxidative stress defence.
The Biochemical journal
journal-article
Towards New Tools to Fight Tuberculosis
Vaccine and Infectious Disease Organization - International Vaccine Centre, University of Saskatchewan
lecture-speech
Understanding and targeting Mycobacterium tuberculosis virulence and transmission to combat TB
Institut National de la Recherche Scientifique - Institut Armand-Frappier
lecture-speech
Phenotypic profiling of Mycobacterium tuberculosis EspA point mutants reveals that blockage of ESAT-6 and CFP-10 secretion in vitro does not always correlate with attenuation of virulence.
Journal of bacteriology
journal-article
Mycobacterium tuberculosis EspB binds phospholipids and mediates EsxA-independent virulence.
Molecular microbiology
journal-article
Differential characteristics and virulence of Mycobacterium tuberculosis espACD and ESX-1 mutants – revisiting the role of EspA
EMBO conference series - Tuberculosis 2012: Biology, Pathogenesis and Intervention strategies at the Institut Pasteur
conference-poster
A point mutation in cycA partially contributes to the D-cycloserine resistance trait of Mycobacterium bovis BCG vaccine strains.
PloS one
journal-article
Virulence regulator EspR of Mycobacterium tuberculosis is a nucleoid-associated protein.
PLoS pathogens
journal-article
EspD is critical for the virulence-mediating ESX-1 secretion system in Mycobacterium tuberculosis.
Journal of bacteriology
journal-article
Biochemical and immunological characterization of EspD, an atypical ESX-1 secretion-associated protein
Eighth International Conference on the Pathogenesis of Mycobacterial Infections
conference-poster
Mutational Analyses of EspA and Effects on the Mycobacterium tuberculosis ESX-1 Virulence Protein Secretion System
FEMS 2011, 4th Congress of European Microbiologists
conference-poster
EspD plays a critical role in the Mycobacterium tuberculosis ESX-1 secretion system
Keystone Symposia (Joint Meeting) - Tuberculosis: Immunology, Cell Biology and Novel Vaccination Strategies, and Mycobacteria: Physiology, Metabolism and Pathogenesis - Back to the Basics
conference-poster
ESAT-6 secretion-independent impact of ESX-1 genes espF and espG1 on virulence of Mycobacterium tuberculosis.
The Journal of infectious diseases
journal-article
Sigma factor F does not prevent rifampin inhibition of RNA polymerase or cause rifampin tolerance in Mycobacterium tuberculosis.
Journal of bacteriology
journal-article
Towards anti-virulence drugs targeting ESX-1 mediated pathogenesis of Mycobacterium tuberculosis
Drug Discovery Today: Disease Mechanisms
journal-article
Tuberculosis vaccines including recombinant BCG strains expressing alanine dehydrogenase, serine dehydratase and/or glutamine synthetase
United States Patent and Trademark Office, no. 7,611,720
patent
Lsr2 of Mycobacterium tuberculosis is a DNA-bridging protein.
Nucleic acids research
journal-article
Differential productions of lipid virulence factors among BCG vaccine strains and implications on BCG safety.
Vaccine
journal-article
Identification of the lipooligosaccharide biosynthetic gene cluster from Mycobacterium marinum.
Molecular microbiology
journal-article
PimF, a mannosyltransferase of mycobacteria, is involved in the biosynthesis of phosphatidylinositol mannosides and lipoarabinomannan.
The Journal of biological chemistry
journal-article
Mycobacterium bovis BCG vaccines exhibit defects in alanine and serine catabolism.
Infection and immunity
journal-article
Site-directed mutagenesis of acyl carrier protein (ACP) reveals amino acid residues involved in ACP structure and acyl-ACP synthetase activity.
The Journal of biological chemistry
journal-article